• First-author research articles

1. Sicong Zhang*, Robert G. Roeder*. (2025). Resistance of estrogen receptor function to BET bromodomain inhibition is mediated by transcriptional coactivator cooperativity. Nature Structural & Molecular Biology. PMID: 39251822. [*co-correspondence author]. (Highlighted by AACR)

2. Fang R*, Chen X*, Sicong Zhang*, Shi H,* Ye Y, Shi H, Li P, Guo Q, Ma L, He C, and Huang S. (2021). EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma. Nature Communications, PMID: 33420027. (*co-first author) 

3. Sicong Zhang, Zhao BS, Zhou A, Lin K, Zheng S, Lu Z, Chen Y, Sulman E, Xie K, Bögler O, Majumder S, He C, and Huang S. (2017). m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-Like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program. Cancer Cell, PMID: 28344040.
(Preview in Cancer Cell; Highlighted by Cancer Discovery) 

4. Gong AH*, Wei P*, Sicong Zhang*, Yao J, Yuan Y, Zhou AD, Lang FF, Heimberger AB, Rao G, Huang S. (2015). FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells. Cancer Research. PMID: 25832656. (*co-first author) 

• Other research articles
5. Li L, Zhou A, Wei Y, Liu F, Li P, Fang R, Ma L, Sicong Zhang, Wang L, Liu J, Richard HT, Chen Y, Wang H, Huang S. (2022). Critical role of lncEPAT in coupling dysregulated EGFR pathway and histone H2A deubiquitination during glioblastoma tumorigenesis. Science Advances. PMID: 36197973.

6. Chang G, Shi L, Ye Y, Shi H, Zeng L, Tiwary S, Huse J, Huo L, Ma L, Ma Y, Sicong Zhang, Zhu J, Xie V, Li P, Han L, He C, and Huang S. (2020). YTHDF3 Induces the Translation of m6A-enriched Metastasis-associated Gene Transcripts to Promote Breast Cancer Brain Metastasis. Cancer Cell, PMID: 33125861.

 
7. Chen Y, Fang R, Yue C, Chang G, Li P, Guo Q, Wang J, Zhou A, Sicong Zhang, Fuller G, Shi X, Huang S. (2020). Wnt-Induced stabilization of KDM4C is required for Wnt/β-Catenin target gene expression and glioblastoma tumorigenesis. Cancer Research. PMID: 31888886.

8. Ma L, Lin K, Chang G, Chen Y, Yue C, Guo Q, Sicong Zhang, Jia Z, Huang TT, Zhou A, Huang S. (2019). Aberrant activation of β-catenin signaling drives glioma tumorigenesis via USP1-mediated stabilization of EZH2. Cancer Research, PMID: 30425057

9. Zhou A, Lin K, Sicong Zhang, Xue J, Morris SA and Huang S. (2017). Gli1-induced deubiquitinase USP48 aids glioma tumorigenesis by deubiquitinating and stabilizing Gli1. EMBO reports, PMID: 28623188.

10. Zhou A, Lin K, Sicong Zhang, Chen Y, Zhang N, Xue J, Wang Z, Aldape KD, Xie K, Woodgett JR, Huang S. (2016). Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22. Nature Cell Biology. PMID: 27501329.

11. Chen Y, Li Y, Xue J, Gong A, Yu G, Zhou A, Lin K, Sicong Zhang, Zhang N, Gottardi CJ, Huang S. (2016). Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation. The EMBO Journal. PMID: 26912724.

12. Xue J, Chen Y, Wu Y, Wang Z, Zhou A, Sicong Zhang, Lin K, Aldape K, Majumder S, Lu Z, Huang S. (2015). Tumour suppressor TRIM33 targets nuclear β-catenin degradation. Nature Communications. PMID: 25639486.

• Invited reviews or commentaries
13. Sicong Zhang*, RG Roeder*. (2020). The Long and the Short of BRD4: Two Tales in Breast Cancer. Molecular Cell. PMID: 32559427. (*co-correspondence author)

14. Sicong Zhang. (2018). Mechanism of N6-methyladenosine modification and its emerging role in cancer. Pharmacology & Therapeutics. PMID: 29730276.

15. Wang Z, Sicong Zhang, Siu TL, Huang S. (2015). Glioblastoma Multiforme Formation and EMT: Role of FoxM1 Transcription Factor. Current Pharmaceutical Design. PMID: 25506897.

16. Li Y, Sicong Zhang, Huang S. (2012). FoxM1: a potential drug target for glioma. Future Oncology. PMID: 22409458.

• Invited book chapters
Sicong Zhang. (2019). ‘The Role of mRNA m6A in Regulation of Gene Expression’ in “The DNA, RNA, and Histone Methylomes”. Cham: Springer, pp 353-376.