Research
Research Focus
Our research aims to understand how cancer cells reprogram gene expression to grow, adapt, and resist therapy. We focus on the molecular mechanisms that control transcription, the process by which genes are turned on and off, and how this regulation is hijacked in cancer. By uncovering these fundamental processes, we seek to identify new therapeutic vulnerabilities and develop strategies to overcome treatment resistance in cancers such as breast cancer and glioblastoma.
1. Transcriptional Control in Cancer
We study how transcriptional cofactors work with key regulatory proteins to control gene expression in cancer cells. Our goal is to uncover how these interactions drive tumor growth and identify new targets for therapy.
2. Therapy Resistance and Cellular Plasticity
Cancer cells can adapt to treatment by rewiring their gene expression programs. We investigate how tumors transition between different cellular states to escape therapies, particularly in breast cancer.
3. Mechanisms of Chemotherapy Resistance
Many cancers survive chemotherapy by entering reversible states that allow them to recover and regrow. We aim to understand the molecular basis of this process and identify ways to prevent relapse.